MORUJÃO, Maria do Rosário Barbosa (coord.), Testementi Ecclesiae Portugaliae (1071-1325)

Barbosa A conversation with Frederico Simões Barbosa

- Luciano Barbosa

For the past ten years, I have worked on several problems related to finding and organizing Web data. From 1999 to 2002, I was a lead developer for Radix, one of the first Brazilian search engines. During my Masters, I designed and implemented a Web crawling policy that uses classification techniques to efficiently update a search engine index while maximizing its freshness [11]. After finishin...

Dmd058420 1314..1325

GSK1322322 (N-((R)-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-2-methylpyrimidin-4-yl) hydrazinyl)-3-oxopropyl)-N-hydroxy-formamide) is an antibiotic in development by GlaxoSmithKline. In this study, we investigated the metabolism and disposition of [C]GSK1322322 in healthy humans and demonstrated the utility of the Entero-Test in a human radiolabel...

NpgRj_ng_1423 1065..1071

The intranuclear position of many genes has been correlated with their activity state, suggesting that migration to functional subcompartments may influence gene expression. Indeed, nascent RNA production and RNA polymerase II seem to be localized into discrete foci or ‘transcription factories’. Current estimates from cultured cells indicate that multiple genes could occupy the same factory, al...

Dmd065201 1316..1325

Several nuclear receptor (NR) superfamily members are known to be the molecular target of either the small ubiquitin-related modifier (SUMO) or ubiquitin-signaling pathways. However, little is currently known regarding how these two post-translational modifications interact to control NR biology. We show that SUMO and ubiquitin circuitry coordinately modifies the pregnane X receptor (PXR, NR1I2...